Description

Calcitriol is the biologically active form of Vitamin D3, a potent secosteroid hormone essential for regulating calcium and phosphate homeostasis in the body. This high-purity compound is critical for advanced pharmaceutical research and development, particularly in therapies targeting bone metabolism and cellular differentiation. It is a key active pharmaceutical ingredient (API) and reference standard for manufacturers in the pharmaceutical, biotechnology, and nutraceutical industries developing treatments for conditions such as hypocalcemia, osteoporosis, and psoriasis.

Application

• Pharmaceutical API: Primary active ingredient in prescription medications for treating hypocalcemia in patients with chronic kidney disease and hypoparathyroidism.
• Oncology Research: Investigated for its role in cell differentiation and proliferation, with applications in cancer research and potential adjuvant therapies.
• Dermatological Formulations: Used in topical treatments for psoriasis due to its effects on skin cell growth and immune modulation.
• Metabolic Bone Disorder Treatments: Essential component in drugs for managing osteoporosis, renal osteodystrophy, and vitamin D-resistant rickets.
• Reference Standard: Serves as a high-purity chemical reference standard (CRS) for quality control and analytical method development in regulatory laboratories.
• Biochemical Research: Used in life science research to study Vitamin D receptor (VDR) signaling pathways, gene expression, and mineral metabolism.
• Nutraceutical Development: Employed in the formulation of advanced dietary supplements targeting bone and immune health (subject to regional regulations).

Basic Information

Product Name	Calcitriol
CAS No.	343969-40-4
Molecular Formula	C₂₇H₄₄O₃
Molecular Weight	416.64 g/mol
Synonyms	1,25-Dihydroxycholecalciferol; 1,25-Dihydroxyvitamin D3; 1,25(OH)₂D₃; Rocaltrol (trade name); Calcijex (trade name); (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol; 1α,25-Dihydroxyvitamin D₃
EINECS	Contact for details

Quality Control

Our Calcitriol is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical actives. Each batch is tested against comprehensive specifications, including identity, purity, and impurity profiles, utilizing advanced analytical techniques like HPLC and spectroscopy. A Certificate of Analysis (COA) is provided with each shipment, detailing all test results. Production can be aligned with current Good Manufacturing Practice (cGMP) standards and relevant pharmacopoeial monographs (USP, EP, JP) upon request to support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) or refrigerated (2-8°C) as specified. The product is strictly light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures must be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.