Description

4-Tosylpiperazin-2-One CAS NO 343323-86-4 is a high-purity pharmaceutical intermediate and organic building block characterized by its piperazinone core functionalized with a tosyl protecting group. This compound is of significant value in medicinal chemistry for the synthesis of complex molecules, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas. It is primarily utilized by research institutions, contract research organizations (CROs), and active pharmaceutical ingredient (API) manufacturers engaged in the development of novel drug candidates.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of potential drug candidates, especially those with piperazine or piperazinone pharmacophores.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• API Development: Used in the research and process development stages for new Active Pharmaceutical Ingredients targeting neurological and psychiatric conditions.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes to study biological pathways and enzyme functions.
• Custom Synthesis: A starting material for contract manufacturing organizations (CMOs) specializing in custom organic synthesis for client-specific projects.

Basic Information

Product Name	4-Tosylpiperazin-2-One
CAS No.	343323-86-4
Molecular Formula	C11H14N2O3S
Molecular Weight	254.31 g/mol
Synonyms	1-Tosylpiperazin-2-one; 2-Piperazinone, 1-[(4-methylphenyl)sulfonyl]-; 1-(4-Methylbenzenesulfonyl)piperazin-2-one; 1-(p-Tolylsulfonyl)piperazin-2-one; 4-Methyl-N-(2-oxopiperazin-1-yl)benzenesulfonamide; 4-Tosyl-2-piperazinone; Tosylpiperazinone
EINECS	Contact for details

Quality Control

Our 4-Tosylpiperazin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.