Description

Nebentan Potassium CAS NO 342005-82-7 is a high-purity potassium salt of the endothelin receptor antagonist nebentan. This compound is a critical advanced pharmaceutical intermediate, valued for its role in the synthesis of potent and selective therapeutic agents targeting cardiovascular and renal diseases. It is primarily required by pharmaceutical R&D laboratories and manufacturing facilities engaged in the development and production of next-generation endothelin receptor antagonists.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of nebentan and related endothelin receptor antagonist drug substances.
• Cardiovascular Drug Research: Used in preclinical and clinical research for developing treatments for pulmonary arterial hypertension (PAH) and heart failure.
• Renal Pharmacology Studies: Employed in the development of therapeutic agents for chronic kidney diseases and other renal disorders mediated by endothelin.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Process Chemistry: Utilized in scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) in the endothelin antagonist class.

Basic Information

Product Name	Nebentan Potassium
CAS No.	342005-82-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Nebentan Potassium Salt; Potassium Nebentan; 5-(Dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide Potassium Salt; BMS-193884 Potassium Salt; Endothelin A Receptor Antagonist Potassium Salt
EINECS	Contact for details

Quality Control

Our Nebentan Potassium is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, assay, and impurity profiling, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) documenting purity, related substances, and residual solvents are available upon request to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.