Description

Alagebrium Chloride is a pharmaceutical-grade advanced glycation end-product (AGE) breaker and cross-link breaker. This compound is of significant interest for research and development in metabolic and age-related disorders. It is primarily utilized by pharmaceutical companies and research institutions focused on cardiometabolic health, anti-aging therapeutics, and diabetic complications. The product is supplied as a high-purity reference standard and active pharmaceutical ingredient (API) intermediate, meeting stringent quality requirements for preclinical and clinical studies.

Application

• Pharmaceutical R&D: Serves as a key intermediate or reference standard in the development of therapeutics targeting AGE-related pathologies.
• Metabolic Disorder Research: Used in preclinical studies investigating treatments for diabetic complications, including nephropathy, retinopathy, and cardiovascular stiffness.
• Anti-Aging & Gerontology Research: Applied in research models studying the reversal of age-related tissue cross-linking and improving vascular compliance.
• Biochemical Research: Functions as a tool compound for studying the biochemical pathways of glycation and protein cross-linking in vitro.
• Contract Manufacturing: Supplied as a certified starting material for the cGMP synthesis of finished dosage forms in clinical trials.
• Academic Research: Provided to university laboratories for fundamental research into the molecular mechanisms of AGEs.

Basic Information

Product Name	Alagebrium Chloride
CAS No.	341028-37-3
Molecular Formula	C19H22ClN3O4
Molecular Weight	391.85 g/mol
Synonyms	ALT-711; 4-[(4,6-Dimethyl-2-pyrimidinyl)thio]-3-[[2-(2-methylphenoxy)ethyl]amino]phenol hydrochloride; 3-[[2-(2-Methylphenoxy)ethyl]amino]-4-[(4,6-dimethyl-2-pyrimidinyl)thio]phenol hydrochloride; Phenol, 3-[[2-(2-methylphenoxy)ethyl]amino]-4-[(4,6-dimethyl-2-pyrimidinyl)thio]-, hydrochloride (1:1); Alagebrium HCl; AGE Breaker ALT-711
EINECS	Contact for details

Quality Control

Our Alagebrium Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, identification by IR and NMR, and stringent control of residual solvents and impurities. We provide full traceability and support regulatory filings. Certificates of Analysis (COA) detailing all test results are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.