Description

1-[4-(Trifluoromethoxy)Benzyl]Piperazine is a high-purity, specialized organic building block featuring a benzylpiperazine core modified with a trifluoromethoxy substituent. This compound is valued for its role as a critical intermediate in the synthesis of advanced pharmaceutical candidates and agrochemicals, where its unique structure imparts desirable metabolic stability and bioavailability. It is primarily sought by research institutions, custom synthesis houses, and manufacturers in the life sciences sector developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the trifluoromethoxy group can enhance biological activity and environmental persistence.
• Chemical Research & Development: Serves as a versatile building block for medicinal chemists to explore structure-activity relationships (SAR) and create new chemical libraries.
• Ligand and Catalyst Preparation: Can be utilized to synthesize complex ligands for catalysis or as a component in material science applications.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP guidelines.

Basic Information

Product Name	1-[4-(Trifluoromethoxy)Benzyl]Piperazine
CAS No.	340759-27-5
Molecular Formula	C12H15F3N2O
Molecular Weight	260.26 g/mol
Synonyms	1-[(4-Trifluoromethoxy)phenyl]methylpiperazine; 4-(Trifluoromethoxy)benzylpiperazine; α-(4-Trifluoromethoxyphenyl)-1-piperazinemethane; 1-[[4-(Trifluoromethoxy)phenyl]methyl]piperazine; Piperazine, 1-[[4-(trifluoromethoxy)phenyl]methyl]-; 340759-27-5; 1-(4-Trifluoromethoxy-benzyl)-piperazine
EINECS	Contact for details

Quality Control

Our 1-[4-(Trifluoromethoxy)Benzyl]Piperazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments. Our quality commitment supports applications requiring high-purity intermediates for research and regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.