Description

tert-Butyl 4-(4-Chlorobenzyl)Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate and versatile organic building block. This compound is critical for the synthesis of complex molecules, offering a protected piperidine scaffold for medicinal chemistry research and process development. It is primarily utilized by R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic agents.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies due to its versatile piperidine core and protective tert-butoxycarbonyl (Boc) group.
• Process Chemistry Development: Serves as a starting material or intermediate in scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Agrochemical Synthesis: Intermediate in the production of advanced crop protection agents and pesticides.
• Custom Synthesis & Contract Manufacturing: A valuable substrate for custom chemical synthesis services targeting novel molecular entities.
• Academic Research: Used in university and institutional labs for methodological development and exploring new organic reactions.

Basic Information

Product Name	tert-Butyl 4-(4-Chlorobenzyl)Piperidine-1-Carboxylate
CAS No.	338467-12-2
Molecular Formula	C17H24ClNO2
Molecular Weight	309.83 g/mol
Synonyms	1-Boc-4-(4-Chlorobenzyl)piperidine; tert-Butyl 4-[(4-Chlorophenyl)methyl]piperidine-1-carboxylate; 4-(4-Chlorobenzyl)piperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(4-chlorobenzyl)piperidine; N-Boc-4-(4-Chlorobenzyl)piperidine; Boc-4-(4-Chlorobenzyl)piperidine; Piperidine-1-carboxylic acid, 4-[(4-chlorophenyl)methyl]-, 1,1-dimethylethyl ester; 338467-12-2
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(4-Chlorobenzyl)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with every shipment, detailing comprehensive specifications. We support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.