Description

1-(4-Fluoro-Benzenesulfonyl)-Piperazine Hydrochloride is a high-purity sulfonamide derivative and a key pharmaceutical intermediate. This compound matters for its role in the synthesis of complex molecules, particularly in medicinal chemistry where it serves as a versatile building block for drug discovery and development. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Agrochemical Synthesis: Serves as a precursor in the development of novel pesticides and herbicides, leveraging the sulfonamide moiety for biological activity.
• Fine Chemical Production: Employed in custom synthesis and contract manufacturing for specialized chemical entities requiring a fluoro-benzenesulfonyl piperazine scaffold.
• Bioconjugation & Probe Development: Useful in creating chemical probes and affinity labels for biochemical and proteomic research due to its reactive functional groups.

Basic Information

Product Name	1-(4-Fluoro-Benzenesulfonyl)-Piperazine Hydrochloride
CAS No.	333986-41-7
Molecular Formula	C10H14ClFN2O2S
Molecular Weight	280.75 g/mol
Synonyms	1-[(4-Fluorophenyl)sulfonyl]piperazine hydrochloride; 4-Fluorobenzenesulfonylpiperazine hydrochloride; N-(4-Fluorophenylsulfonyl)piperazine hydrochloride; Piperazine, 1-[(4-fluorophenyl)sulfonyl]-, hydrochloride (1:1); 4-Fluoro-N-(piperazin-1-ylsulfonyl)aniline hydrochloride; 1-(4-Fluorobenzenesulfonyl)piperazine HCl; 4-Fluorophenyl piperazin-1-yl sulfone hydrochloride
EINECS	Contact for details

Quality Control

Our 1-(4-Fluoro-Benzenesulfonyl)-Piperazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.