Description

O,O′-Bis(2-Aminoethyl)Polyethylene Glycol is a heterobifunctional polyethylene glycol (PEG) derivative featuring primary amine groups at both termini, making it a versatile building block for bioconjugation and polymer chemistry. This compound is essential for creating stable, hydrophilic linkers in the development of advanced pharmaceuticals, diagnostics, and biomaterials. It is primarily utilized by researchers and manufacturers in the biopharmaceutical, nanotechnology, and advanced materials sectors for PEGylation, cross-linking, and surface functionalization.

Application

• PEGylation Reagent: Used to conjugate therapeutic proteins, peptides, and oligonucleotides to improve solubility, stability, and circulation half-life.
• Cross-linking Agent: Serves as a hydrophilic spacer or linker in the synthesis of hydrogels, polymer networks, and dendrimers.
• Surface Modification: Functionalizes nanoparticles, quantum dots, and diagnostic assay surfaces to enhance biocompatibility and reduce non-specific binding.
• Drug Delivery Systems: A key intermediate in constructing drug-polymer conjugates and stimuli-responsive nanocarriers for targeted therapy.
• Biomaterial Fabrication: Incorporated into scaffolds and coatings to impart antifouling properties and promote specific cellular interactions.
• Diagnostic Probe Synthesis: Facilitates the attachment of targeting ligands, dyes, or contrast agents to detection platforms.

Basic Information

Product Name	O,O′-Bis(2-Aminoethyl)Polyethylene Glycol
CAS No.	332941-25-0
Molecular Formula	C2n+4H4n+12N2On+1 (n = PEG repeat units)
Molecular Weight	Variable (dependent on PEG chain length). Contact for details.
Synonyms	α,ω-Bis(2-aminoethyl)poly(ethylene glycol); Diamino-PEG; PEG-bis(amine); Bis(2-aminoethyl) PEG; Poly(ethylene glycol) bis(2-aminoethyl) ether; Amino-PEG-Amine; NH2-PEG-NH2; PEG diamine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical applications. Each batch is characterized to confirm molecular weight distribution (by GPC), amine content, and purity. Certificates of Analysis (COA) detailing specifications such as assay, polydispersity index (PDI), and endotoxin levels are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and potentially oxidizable nature. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Assay (Amine Value)	> 95%
Average Molecular Weight (GPC)	As per ordered grade (e.g., 1kDa, 2kDa, 3.4kDa, 5kDa, 10kDa, 20kDa)
Polydispersity Index (PDI)	≤ 1.05
Water Content (KF)	< 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.