Description

(4-Phenylpiperazin-1-Yl)(4-(Piperidin-1-Ylsulfonyl)Phenyl)Methanone is a high-purity, advanced pharmaceutical intermediate featuring a unique sulfonamide-linked piperazine and piperidine scaffold. This compound is valued for its role as a critical building block in the synthesis of novel bioactive molecules, particularly in central nervous system (CNS) and receptor-targeted drug discovery. It is essential for research and development chemists, medicinal chemistry programs, and manufacturers of active pharmaceutical ingredients (APIs) targeting neurological and psychiatric disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting serotonin, dopamine, or sigma receptors.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• CNS Drug Development: Serves as a core structure for developing potential therapeutics for conditions such as schizophrenia, depression, anxiety, and cognitive disorders.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and receptor interactions in biological systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of non-commercial and clinical trial materials.

Basic Information

Product Name	(4-Phenylpiperazin-1-Yl)(4-(Piperidin-1-Ylsulfonyl)Phenyl)Methanone
CAS No.	325694-84-6
Molecular Formula	C22H27N3O3S
Molecular Weight	413.54 g/mol
Synonyms	1-[4-(Piperidine-1-sulfonyl)benzoyl]-4-phenylpiperazine; 4-Phenyl-1-[[4-(1-piperidinylsulfonyl)phenyl]carbonyl]piperazine; Methanone, (4-phenyl-1-piperazinyl)[4-(1-piperidinylsulfonyl)phenyl]-; 4-Phenyl-1-(4-(piperidine-1-sulfonyl)benzoyl)piperazine; [4-(Piperidine-1-sulfonyl)phenyl]-(4-phenylpiperazin-1-yl)methanone
EINECS	Contact for details

Quality Control

Our (4-Phenylpiperazin-1-Yl)(4-(Piperidin-1-Ylsulfonyl)Phenyl)Methanone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and supporting regulatory filings for research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.