Description

1-Stearoyl-2-Hydroxy-Sn-Glycero-3-Phosphate (Sodium Salt) is a high-purity, synthetic phospholipid derivative, specifically a lysophosphatidic acid (LPA) analogue with a saturated C18 fatty acyl chain. This compound serves as a critical biochemical research tool and a key intermediate in the synthesis of complex lipids and lipid-based drug delivery systems. It is essential for researchers and manufacturers in pharmaceutical development, lipidomics, and advanced material science, where precise molecular structure and purity are paramount for reliable experimental and production outcomes.

Application

• Biochemical & Pharmaceutical Research: As a standard and substrate for studying lysophosphatidic acid (LPA) receptor signaling pathways, enzyme kinetics (e.g., phospholipases), and lipid metabolism.
• Lipidomics & Analytical Standards: Used as a high-purity reference standard in mass spectrometry (LC-MS/MS) for the identification and quantification of phospholipids in complex biological samples.
• Drug Delivery System Development: A key building block for synthesizing functionalized liposomes, lipid nanoparticles (LNPs), and other advanced carriers for targeted drug and gene delivery.
• Cell Culture & Membrane Biology: Employed in model membrane studies to investigate lipid-protein interactions, membrane fluidity, and vesicle formation.
• Chemical Synthesis Intermediate: Serves as a versatile precursor for the semi-synthesis of other complex glycerophospholipids and labeled lipid probes.
• Cosmetic & Dermal Research: Investigated for its potential role in skin barrier function and as a component in advanced topical formulations.

Basic Information

Product Name	1-Stearoyl-2-Hydroxy-Sn-Glycero-3-Phosphate (Sodium Salt)
CAS No.	325465-92-7
Molecular Formula	C21H42NaO7P
Molecular Weight	460.51 g/mol
Synonyms	1-Stearoyl-2-hydroxy-sn-glycero-3-phosphate sodium salt; LPA(18:0) sodium salt; Lysophosphatidic acid (18:0) sodium salt; 1-Octadecanoyl-2-hydroxy-sn-glycero-3-phosphate sodium salt; sn-Glycero-3-phosphoric acid 1-octadecanoyl-2-hydroxy monosodium salt; (2R)-2-Hydroxy-3-(phosphonooxy)propyl octadecanoate sodium salt; 1-Stearoyl LPA sodium salt; LysoPA(18:0) (Na)
EINECS	Contact for details

Quality Control

Our 1-Stearoyl-2-Hydroxy-Sn-Glycero-3-Phosphate (Sodium Salt) is produced under stringent conditions to ensure batch-to-batch consistency and high chemical purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous internal quality standards, and specifications can be tailored to meet specific project requirements. COAs are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). For long-term storage, keep containers sealed in a dry, inert atmosphere. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay (Titration)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0 %
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.