Description

18:0-20:4 Pg is a specific, high-purity phosphatidylglycerol (PG) lipid species characterized by its defined fatty acid composition of stearic acid (18:0) at the sn-1 position and arachidonic acid (20:4) at the sn-2 position. This precise molecular structure is critical for advanced research and development in lipidomics, membrane biophysics, and the formulation of sophisticated drug delivery systems. It serves as an essential biochemical tool and a potential functional excipient for scientists and formulators in the pharmaceutical, biotechnology, and advanced cosmetic industries.

Application

• Biochemical Research & Lipidomics: Used as a standard or substrate in studies of phospholipid metabolism, membrane dynamics, and lipid signaling pathways.
• Liposome & Nanoparticle Formulation: Acts as a key component in the creation of specialized liposomes and lipid nanoparticles (LNPs) for targeted drug and gene delivery.
• Model Membrane Systems: Incorporated into artificial membranes (e.g., vesicles, bilayers) to study the biophysical effects of specific, unsaturated phospholipids on membrane fluidity and protein interactions.
• Pharmaceutical Excipient Development: Investigated for its potential as a functional, anionic phospholipid in pulmonary surfactant formulations or other advanced therapeutic products.
• Cell Culture & Media Supplements: Employed in specialized cell culture applications to study the impact of specific lipid species on cellular function and growth.
• Analytical Reference Standard: Serves as a high-purity quantitative and qualitative standard in HPLC, LC-MS, and other chromatographic analyses.

Basic Information

Product Name	18:0-20:4 Pg
CAS No.	322647-50-7
Molecular Formula	C46H81O10P
Molecular Weight	825.11 g/mol
Synonyms	1-Stearoyl-2-arachidonoyl-sn-glycero-3-phospho-(1'-rac-glycerol); 18:0-20:4 PG; SAPG; Phosphatidylglycerol(18:0/20:4); PG(18:0/20:4); 1-Octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-rac-glycerol); (2R)-2,3-Dihydroxypropyl (2R)-3-(octadecanoyloxy)-2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyloxy]propyl hydrogen phosphate
EINECS	Contact for details

Quality Control

Every batch of 18:0-20:4 Pg is produced and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including advanced chromatographic methods, to ensure compliance with exacting research and development standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen). This product is hygroscopic (moisture-sensitive) and easily oxidized. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or film
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95% (Area %)
Purity (TLC)	Single major spot
Fatty Acid Profile (GC)	Stearic Acid (C18:0): ~50% Arachidonic Acid (C20:4): ~50%
Solubility	Soluble in chloroform, methanol, ethanol; insoluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.