Description

(2R,4S)-n-Boc-4-Hydroxypiperidine-2-Carboxylic Acid Methyl Ester is a high-purity, chiral piperidine derivative that serves as a critical advanced intermediate in modern organic synthesis. Its value lies in the precise stereochemistry and protected functional groups, which enable efficient, multi-step construction of complex molecules with high enantiomeric purity. This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries, particularly for synthesizing active pharmaceutical ingredients (APIs) and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of protease inhibitors, receptor antagonists, and other small-molecule therapeutics.
• Peptidomimetic Chemistry: Used to incorporate constrained, non-natural amino acid motifs into peptide backbones to enhance stability and bioavailability.
• Asymmetric Synthesis: Employed in the construction of complex natural products and other chiral targets requiring the (2R,4S) stereochemistry.
• Agrochemical Research: Serves as a precursor in the development of novel, stereochemically-defined pesticides and herbicides.
• Chemical Biology Probes: Utilized to create labeled or tagged molecular tools for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects at various scales, from laboratory to pilot plant.

Basic Information

Product Name	(2R,4S)-n-Boc-4-Hydroxypiperidine-2-Carboxylic Acid Methyl Ester
CAS No.	321744-26-7
Molecular Formula	C₁₂H₂₁NO₅
Molecular Weight	259.30 g/mol
Synonyms	Methyl (2R,4S)-1-(tert-butoxycarbonyl)-4-hydroxypiperidine-2-carboxylate; (2R,4S)-1-Boc-4-hydroxypiperidine-2-carboxylic acid methyl ester; (2R,4S)-1-(tert-Butoxycarbonyl)-4-hydroxypiperidine-2-carboxylic Acid Methyl Ester; (2R,4S)-4-Hydroxy-1-Boc-piperidine-2-carboxylic acid methyl ester; (2R,4S)-N-Boc-4-hydroxypiperidine-2-carboxylic acid methyl ester; (2R,4S)-1-Boc-4-hydroxy-2-piperidinecarboxylic acid methyl ester; Methyl (2R,4S)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-2-carboxylate
EINECS	Contact for details

Quality Control

Our production of (2R,4S)-n-Boc-4-Hydroxypiperidine-2-Carboxylic Acid Methyl Ester adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high chemical purity. Quality is verified against comprehensive specifications, including chiral purity (enantiomeric excess), chemical purity (HPLC), and identity confirmation (IR, NMR). A Certificate of Analysis (COA) detailing all test results is provided with each shipment, and we support audits and regulatory documentation for cGMP and ISO 9001 compliant supply chains.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.