Description

2-Piperazinecarboxylic Acid, 1,4-Bis(Phenylmethyl)-, Phenylmethyl Ester, (2R)- is a chiral, protected piperazine derivative of significant interest in advanced organic synthesis. This compound matters as a sophisticated building block for constructing complex molecules, particularly in the pharmaceutical sector where its stereochemistry and functional groups are crucial. It is primarily needed by research and development chemists and process development teams in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and production of novel therapeutic agents, including potential CNS-active drugs and enzyme inhibitors.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or precursor in stereoselective reactions to introduce the (2R)-piperazinecarboxylate moiety into target molecules.
• Peptidomimetics & Drug Discovery: Acts as a constrained scaffold in the design and synthesis of peptidomimetic compounds for medicinal chemistry programs.
• Agrochemical Research: Employed in the development of new, chiral active ingredients for crop protection products.
• Catalyst & Ligand Development: Can be used as a precursor for the synthesis of novel chiral ligands for asymmetric catalysis.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry and for exploring new chemical spaces in corporate and university laboratories.

Basic Information

Product Name	2-Piperazinecarboxylic Acid, 1,4-Bis(Phenylmethyl)-, Phenylmethyl Ester, (2R)-
CAS No.	317822-72-3
Molecular Formula	C26H28N2O2
Molecular Weight	400.52 g/mol
Synonyms	(2R)-1,4-Dibenzyl-2-(benzyloxycarbonyl)piperazine; (R)-1,4-Dibenzyl-2-(benzyloxycarbonyl)piperazine; (R)-1,4-Dibenzyl-2-carbobenzoxypiperazine; (R)-Cbz-Dibenzylpiperazine; (R)-1,4-Dibenzylpiperazine-2-carboxylic Acid Benzyl Ester; Benzyl (2R)-1,4-dibenzyl-2-piperazinecarboxylate; (R)-N,N-Dibenzyl-N'-Cbz-ethylenediamine (cyclic form).
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with a focus on high chiral purity and chemical integrity, critical for sensitive synthetic applications. Certificates of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and related substances are available upon request. Production can be aligned with cGMP guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.