Description

1-Benzyl 4-tert-Butyl 2-(Hydroxymethyl)Piperazine-1,4-Dicarboxylate is a high-purity, multifunctional piperazine derivative serving as a critical building block in advanced organic synthesis. Its value lies in its protected amine and carboxylate groups, which provide orthogonal reactivity for constructing complex molecular architectures with high selectivity. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of complex drug candidates, including protease inhibitors and kinase modulators.
• Peptidomimetic Chemistry: Used as a constrained scaffold to mimic peptide secondary structures in drug discovery.
• Ligand Synthesis: Building block for creating chelating agents and catalysts in asymmetric synthesis.
• Agrochemical Research: Intermediate in the synthesis of novel herbicides and fungicides with specific modes of action.
• Material Science: Monomer or cross-linking agent for specialty polymers and dendrimers.
• Chemical Biology: Useful for synthesizing probes and labeled compounds for biochemical studies.

Basic Information

Product Name	1-Benzyl 4-tert-Butyl 2-(Hydroxymethyl)Piperazine-1,4-Dicarboxylate
CAS No.	317365-33-6
Molecular Formula	C18H26N2O5
Molecular Weight	350.41 g/mol
Synonyms	1-Benzyl 4-(tert-Butoxycarbonyl)-2-(hydroxymethyl)piperazine; 2-(Hydroxymethyl)-1,4-piperazinedicarboxylic acid 1-benzyl 4-(1,1-dimethylethyl) ester; tert-Butyl 2-(hydroxymethyl)-4-(phenylmethyl)-1-piperazinecarboxylate; 1-Boc-4-Cbz-2-(hydroxymethyl)piperazine; N-Boc-N'-Cbz-2-(hydroxymethyl)piperazine; 2-Hydroxymethyl-1,4-piperazinedicarboxylic acid benzyl tert-butyl ester; 1,4-Dicarbobenzyloxy-2-hydroxymethylpiperazine tert-butyl ester; Piperazine-1,4-dicarboxylic acid, 2-(hydroxymethyl)-, 1-benzyl 4-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our 1-Benzyl 4-tert-Butyl 2-(Hydroxymethyl)Piperazine-1,4-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high standards, such as cGMP development and research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.