Description

(S)-1-n-Cbz-Piperazine-2-Carboxylic Acid Methyl Ester is a high-purity chiral piperazine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a protected, stereochemically defined scaffold essential for constructing complex molecules with high enantiomeric purity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, especially those targeting neurological receptors.
• Peptidomimetic Chemistry: Used to introduce constrained piperazine motifs into peptide backbones to enhance metabolic stability and bioavailability.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis or as pharmacophores in medicinal chemistry programs.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for the custom synthesis of more complex, proprietary compounds for clients.
• Academic Research: Utilized in university and institutional labs for methodological studies in asymmetric synthesis and heterocyclic chemistry.

Basic Information

Product Name	(S)-1-n-Cbz-Piperazine-2-Carboxylic Acid Methyl Ester
CAS No.	314741-63-4
Molecular Formula	C14H18N2O4
Molecular Weight	278.31 g/mol
Synonyms	(S)-1-(Benzyloxycarbonyl)piperazine-2-carboxylic acid methyl ester; (S)-Methyl 1-[(benzyloxy)carbonyl]piperazine-2-carboxylate; (S)-Methyl 1-Cbz-piperazine-2-carboxylate; (S)-1-Cbz-Piperazine-2-carboxylic Acid Methyl Ester; (S)-1-Carbobenzyloxy-piperazine-2-carboxylic Acid Methyl Ester; (S)-Piperazine-2-carboxylic acid, 1-[(phenylmethoxy)carbonyl]-, methyl ester; (S)-1-Z-Piperazine-2-carboxylic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our (S)-1-n-Cbz-Piperazine-2-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.