Description

(S)-1-Boc-3-Hydroxymethyl-Piperazine is a high-purity chiral piperazine derivative, serving as a critical building block in modern organic synthesis. This compound matters for its role as a versatile intermediate in the development of complex, biologically active molecules, enabling precise stereochemical control. It is primarily needed by pharmaceutical and biotechnology R&D teams for the synthesis of active pharmaceutical ingredients (APIs), particularly in the areas of oncology, neurology, and antiviral therapies.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel Active Pharmaceutical Ingredients (APIs) and drug candidates.
• Protease Inhibitor Development: Used in the research and production of protease inhibitors for antiviral and anticancer applications.
• Peptidomimetics & Constrained Peptides: Serves as a scaffold for constructing conformationally restricted peptides to enhance metabolic stability and receptor selectivity.
• Ligand & Catalyst Synthesis: Employed in the preparation of chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology & Medicinal Chemistry: A valuable tool compound for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the scale-up and cGMP production of advanced therapeutic compounds.

Basic Information

Product Name	(S)-1-Boc-3-Hydroxymethyl-Piperazine
CAS No.	314741-40-7
Molecular Formula	C11H22N2O3
Molecular Weight	230.31 g/mol
Synonyms	(S)-1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperazine; (3S)-1-Boc-3-piperazinemethanol; (S)-3-Hydroxymethyl-1-Boc-piperazine; tert-Butyl (3S)-3-(hydroxymethyl)piperazine-1-carboxylate; (S)-1-Boc-3-hydroxymethylpiperazine; (S)-N-Boc-3-piperazinemethanol; (S)-3-(Hydroxymethyl)-1-(tert-butoxycarbonyl)piperazine; (S)-1-Boc-3-piperazinemethanol
EINECS	Contact for details

Quality Control

Our (S)-1-Boc-3-Hydroxymethyl-Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-grade pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.