Description

1-(2-Hydroxy-Phenyl)-Piperazine-4-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its piperazine core and protected carboxylic acid group. This compound matters as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), offering a versatile scaffold for medicinal chemistry. It is primarily needed by research institutions and pharmaceutical manufacturers developing novel therapeutics, particularly in areas requiring sophisticated heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates targeting central nervous system (CNS) disorders, such as antipsychotics and antidepressants.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) that incorporate a functionalized piperazine moiety.
• Chemical Reference Standard: Employed as an analytical standard for quality control and method development in pharmaceutical analysis.
• Custom Synthesis Building Block: Provides a protected carboxylic acid group for selective downstream functionalization in custom synthesis projects.

Basic Information

Product Name	1-(2-Hydroxy-Phenyl)-Piperazine-4-Carboxylic Acid tert-Butyl Ester
CAS No.	313657-51-1
Molecular Formula	C15H22N2O3
Molecular Weight	278.35 g/mol
Synonyms	tert-Butyl 1-(2-hydroxyphenyl)piperazine-4-carboxylate; 4-(tert-Butoxycarbonyl)-1-(2-hydroxyphenyl)piperazine; 1-(2-Hydroxyphenyl)piperazine-4-carboxylic acid tert-butyl ester; 1-(2-Hydroxy-phenyl)-piperazine-4-carboxylic acid tert-butyl ester; 313657-51-1; BOC-Piperazine derivative; 2-Hydroxyphenyl piperazine carboxylate ester
EINECS	Contact for details

Quality Control

Our 1-(2-Hydroxy-Phenyl)-Piperazine-4-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting full specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled and stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.