Description

4-n-Boc-2-Methylpiperazine-Hcl CAS NO 313657-42-0 is a high-purity, protected piperazine derivative widely used as a critical building block in pharmaceutical synthesis. Its primary value lies in serving as a versatile chiral intermediate for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry. This compound is essential for research institutions and manufacturers in the pharmaceutical and biotechnology sectors who require reliable, high-quality intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, including kinase inhibitors and other targeted therapies.
• API Development: Used in the research and scale-up production of Active Pharmaceutical Ingredients (APIs), especially those containing functionalized piperazine cores.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to introduce specific stereochemistry and functional groups.
• Peptidomimetics Synthesis: Serves as a building block for creating peptide-like compounds with enhanced metabolic stability and bioavailability.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and contract research organizations (CROs/CMOs) specializing in small molecule development.

Basic Information

Product Name	4-n-Boc-2-Methylpiperazine-Hcl
CAS No.	313657-42-0
Molecular Formula	C10H21ClN2O2
Molecular Weight	236.74 g/mol
Synonyms	1-Boc-2-Methylpiperazine Hydrochloride; tert-Butyl 2-Methylpiperazine-1-carboxylate Hydrochloride; 4-(tert-Butoxycarbonyl)-2-methylpiperazine Hydrochloride; N-Boc-2-Methylpiperazine HCl; 2-Methyl-1-piperazinecarboxylic Acid 1,1-Dimethylethyl Ester Hydrochloride; Boc-2-Methylpiperazine HCl Salt; (S/R)-1-Boc-2-Methylpiperazine Hydrochloride
EINECS	Contact for details

Quality Control

Our 4-n-Boc-2-Methylpiperazine-Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and chiral purity, NMR for structural confirmation, and KF for moisture content. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.