Description

4-[3-(2-Hydroxyethoxy)-2-Pyrazinyl]-1-Piperazinecarboxylic Acid 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is valued for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated heterocyclic chemistry. It is primarily needed by pharmaceutical R&D laboratories, process development chemists, and manufacturers engaged in the production of novel drug candidates.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug molecules, particularly those containing pyrazine and piperazine pharmacophores.
• API Synthesis: Serves as a key building block for the development and manufacturing of Active Pharmaceutical Ingredients (APIs) targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.
• Process Chemistry & Scale-Up: Used in research and development for route scouting, optimization, and subsequent pilot or commercial-scale production of target compounds.
• Chemical Reference Standard: Employed as a high-purity standard in analytical method development and validation for quality control in pharmaceutical manufacturing.
• Medicinal Chemistry Research: Provides a versatile scaffold for structure-activity relationship (SAR) studies and the discovery of new chemical entities in drug discovery programs.
• Custom Synthesis: Acts as a starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	4-[3-(2-Hydroxyethoxy)-2-Pyrazinyl]-1-Piperazinecarboxylic Acid 1,1-Dimethylethyl Ester
CAS No.	313654-84-1
Molecular Formula	C15H24N4O4
Molecular Weight	324.38 g/mol
Synonyms	tert-Butyl 4-[3-(2-hydroxyethoxy)pyrazin-2-yl]piperazine-1-carboxylate; 1-Boc-4-[3-(2-hydroxyethoxy)-2-pyrazinyl]piperazine; 1-(tert-Butoxycarbonyl)-4-[3-(2-hydroxyethoxy)-2-pyrazinyl]piperazine; 4-[3-(2-Hydroxyethoxy)pyrazin-2-yl]piperazine-1-carboxylic acid tert-butyl ester; BOC-Piperazine-Pyrazine Intermediate; CAS 313654-84-1
EINECS	Contact for details

Quality Control

Our 4-[3-(2-Hydroxyethoxy)-2-Pyrazinyl]-1-Piperazinecarboxylic Acid 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.