Description

(S)-4-[2-Carboxy-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Ethyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a sophisticated, optically pure Fmoc-protected amino acid derivative, serving as a critical building block in solid-phase peptide synthesis (SPPS). Its primary value lies in enabling the precise, racemization-free incorporation of a piperazine moiety, which is essential for modulating the pharmacokinetic and pharmacodynamic properties of therapeutic peptides. This high-purity intermediate is indispensable for research and development laboratories, as well as production facilities, focused on novel peptide-based pharmaceuticals, diagnostic agents, and biochemical tools.

Application

• Pharmaceutical Intermediate: Key raw material for the synthesis of complex therapeutic peptides targeting GPCRs, enzymes, and other biological pathways.
• Solid-Phase Peptide Synthesis (SPPS): Used as a protected amino acid derivative for the controlled, sequential assembly of peptide chains on resin supports.
• Peptidomimetic Drug Development: Incorporates the piperazine scaffold to enhance metabolic stability, solubility, and receptor binding affinity in drug candidates.
• Bioconjugation and Labeling: The carboxylic acid and protected amine functionalities allow for site-specific conjugation to labels, tags, or other biomolecules.
• Chemical Biology Research: Employed in the synthesis of peptide probes and tools for studying protein-protein interactions and cellular signaling.
• API (Active Pharmaceutical Ingredient) Synthesis: Serves as a critical intermediate in the multi-step manufacturing process of peptide-based APIs.

Basic Information

Item	Details
Product Name	(S)-4-[2-Carboxy-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Ethyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	313052-20-9
Molecular Formula	C31H33N3O6
Molecular Weight	543.61 g/mol
Synonyms	Fmoc-Pip(2-COOH)-OH; Fmoc-4-(2-Carboxy-2-aminoethyl)piperazine-1-carboxylic acid tert-butyl ester; (S)-Fmoc-4-(2-Carboxy-2-aminoethyl)piperazine-1-Boc; 1-Boc-4-[(2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-2-carboxyethyl]piperazine; Fmoc-L-4-(2-Carboxy-2-aminoethyl)piperazine-1-Boc; N-α-Fmoc-N-δ-Boc-L-diaminopropionic acid piperazine derivative; Boc-Pip(Fmoc)-OH; Fmoc-Dpr(Pip-Boc)-OH
EINECS	Contact for details

Quality Control

Our production of (S)-4-[2-Carboxy-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Ethyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral HPLC to confirm enantiomeric purity and ensure the absence of racemization. We provide full traceability and Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, supporting compliance with cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Identification (IR)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (S-enantiomer)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.