Description

A-[[Fmoc]Amino]-1-[Alloc]-(As)-4-Piperidinepropanoic Acid is a sophisticated, dual-protected amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound is engineered to provide orthogonal protection, allowing for the selective deprotection of the Alloc group in the presence of the Fmoc group, which is critical for the synthesis of complex peptides and peptidomimetics. It is an essential building block for pharmaceutical researchers and peptide chemists in drug discovery, particularly for developing therapeutic peptides, constrained analogs, and molecular probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the sequential assembly of complex peptide chains using Fmoc/Alloc orthogonal protection strategies.
• Peptidomimetic Drug Discovery: Used to incorporate constrained, non-natural amino acid motifs into peptide backbones to enhance metabolic stability, bioavailability, and target binding affinity.
• Combinatorial Chemistry Libraries: Serves as a valuable scaffold for generating diverse libraries of peptide-based compounds for high-throughput screening.
• Synthesis of Bioconjugates: The Alloc protecting group can be selectively removed under mild conditions (e.g., using Pd(0)) for subsequent conjugation to labels, tags, or other biomolecules.
• Research & Development of Novel Therapeutics: Critical for academic and industrial R&D focused on oncology, metabolic disorders, and infectious diseases where peptide therapeutics show promise.
• Process Development & Scale-Up: Supports the transition from milligram-scale research to gram and kilogram-scale production for preclinical and clinical trial material.

Basic Information

Product Name	A-[[Fmoc]Amino]-1-[Alloc]-(As)-4-Piperidinepropanoic Acid
CAS No.	313052-03-8
Molecular Formula	C29H34N2O6
Molecular Weight	506.60 g/mol
Synonyms	1-[(Allyloxy)carbonyl]-4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]piperidine-4-propanoic Acid; Fmoc-Asu(Alloc)-OH; (3S)-3-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-[(2-propen-1-yloxy)carbonyl]amino]butanoic Acid (related analog); Nα-Fmoc-Nδ-Alloc-L-2,4-diaminobutanoic Acid derivative; 4-[(Allyloxy)carbonyl]amino]-1-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]piperidine-4-propionic Acid; Fmoc-Asu(Alloc)-OH (Piperidine-based); Protected Diamino Acid Derivative; Orthogonally Protected Amino Acid for SPPS
EINECS	Contact for details

Quality Control

Our production of A-[[Fmoc]Amino]-1-[Alloc]-(As)-4-Piperidinepropanoic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, critical for sensitive peptide synthesis applications. All materials are characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support compliance with cGMP and ISO 9001 standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.