Description

(2R,5S)-2,5-Dimethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, stereochemically defined chiral piperazine derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in providing a protected, enantiomerically pure scaffold for constructing complex molecules with precise stereochemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and fine chemicals where specific chirality is required for biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of novel, enantiomerically pure pesticides and herbicides with enhanced efficacy and environmental profiles.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics: Incorporated into the backbone of peptidomimetic compounds to modulate bioavailability and receptor binding.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects requiring high stereochemical fidelity.
• Academic & R&D: Employed in medicinal chemistry and process chemistry research for exploring new synthetic routes and molecular entities.

Basic Information

Product Name	(2R,5S)-2,5-Dimethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	309915-46-6
Molecular Formula	C11H22N2O2
Molecular Weight	214.31 g/mol
Synonyms	1-Boc-(2R,5S)-2,5-Dimethylpiperazine; (2R,5S)-1-(tert-Butoxycarbonyl)-2,5-dimethylpiperazine; tert-Butyl (2R,5S)-2,5-dimethylpiperazine-1-carboxylate; (2R,5S)-2,5-Dimethyl-1-Boc-piperazine; (2R,5S)-1-N-Boc-2,5-dimethylpiperazine; (2R,5S)-2,5-DMP-Boc; Boc-(2R,5S)-DMP; (2R,5S)-2,5-Dimethylpiperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our (2R,5S)-2,5-Dimethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high enantiomeric purity and chemical identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.