Description

Talmapimod is a potent and selective small molecule inhibitor of p38 mitogen-activated protein kinase (MAPK) alpha, a key enzyme involved in inflammatory signaling pathways. This compound is a critical research tool for investigating the role of p38α in disease models and for the development of novel anti-inflammatory therapeutics. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on immunology, oncology, and autoimmune disorders. Talmapimod CAS NO 309913-83-5 represents a high-purity chemical entity for advanced biological studies.

Application

• Biomedical Research: Used as a reference standard and pharmacological tool to study p38 MAPK signaling cascades in cellular and biochemical assays.
• Drug Discovery & Development: Serves as a lead compound or benchmark inhibitor in high-throughput screening and structure-activity relationship (SAR) studies for inflammatory diseases.
• Preclinical Studies: Employed in animal models to validate the therapeutic potential of p38α inhibition for conditions like rheumatoid arthritis, psoriasis, and chronic obstructive pulmonary disease (COPD).
• Mechanistic Biology: Essential for elucidating the specific roles of p38α versus other MAPK isoforms in cellular stress response, apoptosis, and cytokine production.
• API Intermediate: Can be used in the synthesis and process development of more advanced p38 inhibitor candidates.

Basic Information

Product Name	Talmapimod
CAS No.	309913-83-5
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	SCIO-469; Doramapimod; BIRB 796 BS; 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl]urea; BIRB 796; BIRB-796; p38 MAP kinase inhibitor BIRB 796
EINECS	Contact for details

Quality Control

Our Talmapimod is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the material under inert atmosphere (e.g., argon or nitrogen) to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.