Description

3,8-Dioxatricyclo[3.2.1.02,4]Octane-6,7-Dicarboxylicacid,(1R,2S,4R,5S)-Rel-(9Ci) is a high-purity, stereochemically defined bicyclic compound that serves as a sophisticated chiral building block and intermediate in advanced organic synthesis. Its rigid, oxygenated tricyclic framework and dual carboxylic acid functionality make it a valuable scaffold for constructing complex molecules with precise three-dimensional architecture. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in asymmetric synthesis, medicinal chemistry, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly those requiring complex, polycyclic core structures.
• Asymmetric Catalyst Ligand Precursor: Used in the synthesis of novel chiral ligands for metal-catalyzed asymmetric reactions, enabling high enantioselectivity.
• Medicinal Chemistry Scaffold: Serves as a constrained, three-dimensional core for constructing focused libraries in drug discovery programs targeting challenging biological receptors.
• Agrochemical Synthesis: An advanced intermediate in the development of new generation herbicides, fungicides, or insecticides with specific stereochemical requirements.
• Material Science Research: Potential monomer or cross-linking agent for developing novel polymers with unique thermal or mechanical properties derived from its rigid bicyclic structure.
• Academic & Industrial R&D: A valuable tool for methodological studies in organic synthesis, particularly in reactions involving strained systems or stereocontrol.

Basic Information

Product Name	3,8-Dioxatricyclo[3.2.1.02,4]Octane-6,7-Dicarboxylicacid,(1R,2S,4R,5S)-Rel-(9Ci)
CAS No.	308831-33-6
Molecular Formula	C8H8O6
Molecular Weight	200.14 g/mol
Synonyms	(1R,2S,4R,5S)-rel-3,8-Dioxatricyclo[3.2.1.02,4]octane-6,7-dicarboxylic acid; Bicyclo[2.2.1]heptane-2,3-dicarboxylic acid, 5,6-dihydro-1,4-dioxa-5,6-epoxy-; 5,6-Epoxy-5,6-dihydro-1,4-dioxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid; rel-(1R,2S,4R,5S)-3,8-Dioxatricyclo[3.2.1.02,4]octane-6,7-dicarboxylic acid; 308831-33-6; Chiral Bicyclic Diacid; Dioxatricyclooctane Dicarboxylic Acid Derivative
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is fully characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and commercial projects requiring compliance with cGMP and other relevant regulatory guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.