Description

1-Propanone, 2-Chloro-1-Tricyclo[3.2.1.02,4]Oct-3-Yl-, [3(S)-(1Alpha,2Beta,3Beta,4Beta,5Alpha)]- (9Ci) is a high-purity, stereochemically defined advanced pharmaceutical intermediate (API intermediate) with the CAS registry number 128913-30-4. This compound is valued for its complex, rigid tricyclic framework, which serves as a critical building block in the synthesis of novel active pharmaceutical ingredients. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of complex small-molecule therapeutics, particularly in areas requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Asymmetric Synthesis: Employed in stereoselective synthesis routes to construct complex molecular architectures with defined three-dimensional configurations.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes from laboratory to pilot and commercial production scales.
• Academic & Industrial R&D: Utilized in advanced organic synthesis research focused on novel ring systems and reaction methodologies.

Basic Information

Product Name	1-Propanone, 2-Chloro-1-Tricyclo[3.2.1.02,4]Oct-3-Yl-, [3(S)-(1Alpha,2Beta,3Beta,4Beta,5Alpha)]- (9Ci)
CAS No.	128913-30-4
Molecular Formula	C11H13ClO
Molecular Weight	196.67 g/mol
Synonyms	2-Chloro-1-(tricyclo[3.2.1.0²,⁴]oct-3-yl)propan-1-one; (1S,2R,3S,4R,5R)-2-Chloro-1-(tricyclo[3.2.1.0²,⁴]oct-3-yl)propan-1-one; [3(S)-(1α,2β,3β,4β,5α)]-2-Chloro-1-tricyclo[3.2.1.0²,⁴]oct-3-yl-1-propanone; 128913-30-4; Tricyclic Chloropropanone Derivative; Advanced Tricyclic Synthon
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems. Each batch is subjected to comprehensive analytical characterization, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and NMR/IR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and cGMP-grade requirements, with quality protocols designed to meet the stringent needs of pharmaceutical R&D and manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound should be considered moisture-sensitive (hygroscopic) and handled under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.