Description

5-[3-(Dimethylamino)Propyl]-10,11-Dihydro-5H-Dibenzo[A,D]Cycloheptene is a key tricyclic organic compound with a tertiary amine functional group, serving as a crucial intermediate in advanced pharmaceutical synthesis. Its molecular architecture makes it a versatile building block for the development of active pharmaceutical ingredients (APIs) targeting the central nervous system. This high-purity intermediate is essential for research institutions and manufacturers engaged in the development and production of specialty pharmaceuticals and fine chemicals.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of complex drug molecules, particularly tricyclic antidepressants and related neuroactive compounds.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a precursor in multi-step synthetic routes for the manufacture of final drug substances.
• Research & Development: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new therapeutic agents.
• Fine Chemical Production: Employed in the synthesis of other specialty chemicals requiring its unique dibenzocycloheptene core structure.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials and commercial APIs.

Basic Information

Product Name	5-[3-(Dimethylamino)Propyl]-10,11-Dihydro-5H-Dibenzo[A,D]Cycloheptene
CAS No.	19660-95-8
Molecular Formula	C20H25N
Molecular Weight	279.42 g/mol
Synonyms	10,11-Dihydro-5-[3-(dimethylamino)propyl]-5H-dibenzo[a,d]cycloheptene; 5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene; Dibenzo[a,d]cycloheptene-5-propylamine, 10,11-dihydro-N,N-dimethyl-; NSC 108034; Amitriptyline Impurity; Amitriptyline Related Compound A; Nortriptyline Intermediate
EINECS	243-196-9

Quality Control

Our 5-[3-(Dimethylamino)Propyl]-10,11-Dihydro-5H-Dibenzo[A,D]Cycloheptene is manufactured under strict quality management systems. We provide material that meets high-purity standards suitable for pharmaceutical R&D and GMP manufacturing. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.