Description

1-Piperazinecarboxylic Acid, 2,5,5-Trimethyl-, 1,1-Dimethylethyl Ester is a high-purity, protected piperazine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in providing a sterically hindered, nitrogen-containing scaffold that is essential for constructing complex molecules with specific pharmacological profiles. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of novel drug candidates, especially those targeting neurological receptors.
• Agrochemical Research: Used in the development of new pesticides and herbicides where a modified piperazine core can enhance biological activity.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal complexation.
• Peptidomimetics & Bioactive Molecule Design: The tert-butyloxycarbonyl (Boc) protected amine and carboxylic acid ester functionalities make it ideal for constructing peptide analogs and other bioactive compounds.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	1-Piperazinecarboxylic Acid, 2,5,5-Trimethyl-, 1,1-Dimethylethyl Ester
CAS No.	308109-96-8
Molecular Formula	C12H24N2O2
Molecular Weight	228.33 g/mol
Synonyms	2,2,6,6-Tetramethyl-4-oxo-piperazine-1-carboxylic acid tert-butyl ester; tert-Butyl 2,2,6,6-tetramethyl-4-oxopiperazine-1-carboxylate; 4-Oxo-2,2,6,6-tetramethylpiperazine-1-carboxylic acid tert-butyl ester; Boc-2,2,6,6-tetramethyl-4-oxopiperazine; 1-Boc-2,2,6,6-tetramethyl-4-oxopiperazine; 1-(tert-Butoxycarbonyl)-2,2,6,6-tetramethyl-4-oxopiperazine; 2,5,5-Trimethylpiperazine-1-carboxylic acid tert-butyl ester; TM-Boc-Pip
EINECS	Contact for details

Quality Control

Our 1-Piperazinecarboxylic Acid, 2,5,5-Trimethyl-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where required, ensuring suitability for use in regulated research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.