Description

1-n-Boc-4-(2-n-Cbz-Aminoethyl)Piperazine is a high-purity, bifunctional piperazine derivative designed for advanced pharmaceutical synthesis and chemical research. This compound serves as a critical, multi-purpose building block, offering orthogonal amine protection with its Boc and Cbz groups to enable complex, sequential synthetic strategies. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing novel drug candidates, particularly in peptide mimetics and small molecule libraries.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and receptor antagonists.
• Peptidomimetic Chemistry: Used to introduce constrained piperazine scaffolds and protected amine functionalities into peptide backbones to enhance metabolic stability and bioavailability.
• Protecting Group Strategy: Enables sequential deprotection in multi-step organic synthesis due to the differential stability of the Boc and Cbz protecting groups under acidic and hydrogenolytic conditions, respectively.
• Chemical Library Development: Employed in combinatorial and parallel synthesis for generating diverse compound libraries for high-throughput screening in drug discovery programs.
• Linker Molecule in Bioconjugation: Can function as a spacer or linker in the development of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• Research & Development: Serves as a standard or reagent in academic and industrial R&D for exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	1-n-Boc-4-(2-n-Cbz-Aminoethyl)Piperazine
CAS No.	302557-32-0
Molecular Formula	C19H29N3O4
Molecular Weight	363.46 g/mol
Synonyms	1-Boc-4-(2-Cbz-aminoethyl)piperazine; tert-Butyl 4-[2-[(benzyloxy)carbonylamino]ethyl]piperazine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-[2-[(benzyloxycarbonyl)amino]ethyl]piperazine; N-Boc-N'-(2-Cbz-aminoethyl)piperazine; 4-(2-((Benzyloxy)carbonylamino)ethyl)-1-(tert-butoxycarbonyl)piperazine; Piperazine, 1-(1,1-dimethylethoxy)carbonyl-4-[2-[[(phenylmethoxy)carbonyl]amino]ethyl]-; Boc-Pip(Cbz-NH-Et); 302557-32-0
EINECS	Contact for details

Quality Control

Our 1-n-Boc-4-(2-n-Cbz-Aminoethyl)Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.