Description

Rosiglitazone Hydrochloride is a high-purity active pharmaceutical ingredient (API) primarily used in research and development. This compound is a potent and selective agonist for the peroxisome proliferator-activated receptor gamma (PPARγ), making it a critical tool in metabolic disease studies. It is essential for pharmaceutical manufacturers, analytical laboratories, and research institutions focused on diabetes, insulin resistance, and related metabolic pathways.

Application

• Pharmaceutical Reference Standard: Serves as a primary standard for the quality control and analytical method development of antidiabetic medications.
• Active Pharmaceutical Ingredient (API) R&D: Used in the formulation research and preclinical development of novel thiazolidinedione-based therapeutics.
• Biochemical Research: A key ligand in studies investigating PPARγ receptor signaling, adipocyte differentiation, and glucose homeostasis.
• Metabolic Disease Modeling: Employed in in vitro and in vivo models to study type 2 diabetes, insulin sensitization, and lipid metabolism.
• Analytical Testing: Used by quality control laboratories for assay validation, impurity profiling, and stability testing of drug products containing rosiglitazone.

Basic Information

Product Name	Rosiglitazone Hydrochloride
CAS No.	302543-62-0
Molecular Formula	C18H19N3O3S • HCl
Molecular Weight	393.88 g/mol (as hydrochloride salt)
Synonyms	5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione monohydrochloride; Avandia (brand name reference); BRL 49653C; Rosiglitazone HCl; PPARγ Agonist; (±)-Rosiglitazone Hydrochloride
EINECS	Contact for details

Quality Control

Our Rosiglitazone Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC, to ensure it meets stringent specifications for pharmaceutical research. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.