Description

4-(3-(3,4-Difluorophenyl)-5,5-Dimethyl-4-Oxo-4,5-Dihydrofuran-2-Yl)Benzenesulfonamide is a high-purity, non-steroidal anti-inflammatory drug (NSAID) intermediate of significant commercial and research interest. This compound is a key synthetic precursor in the development of selective COX-2 inhibitors, which are crucial for creating advanced analgesic and anti-inflammatory pharmaceuticals. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry and novel drug development.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of next-generation COX-2 inhibitor drugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new anti-inflammatory agents with improved efficacy and safety profiles.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Development: Employed in scaling up and optimizing synthetic routes for active pharmaceutical ingredients (APIs) in pilot plants and commercial manufacturing.
• Biochemical Research: Used in vitro studies to investigate the mechanisms of cyclooxygenase enzyme inhibition.

Basic Information

Product Name	4-(3-(3,4-Difluorophenyl)-5,5-Dimethyl-4-Oxo-4,5-Dihydrofuran-2-Yl)Benzenesulfonamide
CAS No.	301692-94-4
Molecular Formula	C18H15F2NO4S
Molecular Weight	379.38 g/mol
Synonyms	4-[3-(3,4-Difluorophenyl)-5,5-dimethyl-4-oxo-2(5H)-furanyl]benzenesulfonamide; 4-(3-(3,4-Difluorophenyl)-5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)benzenesulfonamide; COX-2 Inhibitor Intermediate; Valdecoxib Intermediate; SC-65872 (developmental code); Benzenesulfonamide, 4-[3-(3,4-difluorophenyl)-5,5-dimethyl-4-oxo-2(5H)-furanyl]-; 2(5H)-Furanone, 3-(3,4-difluorophenyl)-5,5-dimethyl-4-[4-(aminosulfonyl)phenyl]-
EINECS	Contact for details

Quality Control

Our 4-(3-(3,4-Difluorophenyl)-5,5-Dimethyl-4-Oxo-4,5-Dihydrofuran-2-Yl)Benzenesulfonamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.