Description

4-(3-(3,5-Difluorophenyl)-5,5-Dimethyl-4-Oxo-4,5-Dihydrofuran-2-Yl)Benzenesulfonamide is a high-purity, advanced pharmaceutical intermediate characterized by its unique sulfonamide-furanone hybrid structure. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with targeted therapeutic effects. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities, particularly for anti-inflammatory and oncology applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates, especially COX-2 inhibitors and other enzyme-targeting therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its modifiable sulfonamide and difluorophenyl groups.
• API Development: Serves as a core scaffold for developing potential anti-inflammatory, analgesic, and anti-cancer agents.
• Biochemical Research: Employed as a tool compound or reference standard in biochemical assays to study enzyme inhibition and cellular pathways.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects.

Basic Information

Product Name	4-(3-(3,5-Difluorophenyl)-5,5-Dimethyl-4-Oxo-4,5-Dihydrofuran-2-Yl)Benzenesulfonamide
CAS No.	301692-68-2
Molecular Formula	C18H15F2NO4S
Molecular Weight	379.38 g/mol
Synonyms	4-[3-(3,5-Difluorophenyl)-5,5-dimethyl-4-oxo-2(5H)-furanylidene]benzenesulfonamide; 4-(3-(3,5-Difluorophenyl)-5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)benzenesulfonamide; 2-[4-(Aminosulfonyl)phenyl]-3-(3,5-difluorophenyl)-5,5-dimethyl-2,5-dihydrofuran-4-one; SC-75416; COX-2 Inhibitor Intermediate; Difluorophenyl Furanone Sulfonamide.
EINECS	Contact for details

Quality Control

Our production of 4-(3-(3,5-Difluorophenyl)-5,5-Dimethyl-4-Oxo-4,5-Dihydrofuran-2-Yl)Benzenesulfonamide adheres to stringent quality management systems. The product undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with batch-specific data are available upon request, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.