Description

1-Boc-3-Hydroxymethyl-Piperazine is a versatile and high-purity Boc-protected piperazine derivative, serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in enabling the precise construction of complex molecular architectures, particularly for active pharmaceutical ingredients (APIs) and fine chemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly for central nervous system (CNS) agents, kinase inhibitors, and antiviral compounds.
• Peptidomimetics & PROTACs: Used to introduce functionalized piperazine scaffolds into peptide backbones and proteolysis-targeting chimeras (PROTACs) for enhanced bioavailability and target engagement.
• Ligand & Catalyst Development: Serves as a precursor for creating sophisticated chiral ligands and organocatalysts used in asymmetric synthesis.
• Agrochemical Synthesis: Employed in the research and production of advanced herbicides and fungicides that require specific stereochemistry.
• Material Science: Acts as a monomer or cross-linking agent in the development of specialty polymers with tailored properties.

Basic Information

Product Name	1-Boc-3-Hydroxymethyl-Piperazine
CAS No.	301673-16-5
Molecular Formula	C11H22N2O3
Molecular Weight	230.31 g/mol
Synonyms	tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperazine; 3-Hydroxymethyl-1-Boc-piperazine; N-Boc-3-piperazinemethanol; 1-N-Boc-3-hydroxymethylpiperazine; 1-Boc-3-piperazinemethanol; Piperazine, 3-(hydroxymethyl)-, 1-(1,1-dimethylethyl) ester; 3-(Hydroxymethyl)-1-piperazinecarboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 1-Boc-3-Hydroxymethyl-Piperazine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP starting material applications. Certificates of Analysis (COA) with full traceability are provided for all shipments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.