Description

tert-Butyl 4-(4-Amino-3-Methylphenyl)piperazine-1-carboxylate is a high-purity, protected piperazine derivative serving as a critical building block in advanced organic synthesis. This compound matters because it provides a versatile and reactive scaffold for constructing complex molecules, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• API (Active Pharmaceutical Ingredient) Synthesis: Serves as a building block in the multi-step synthesis of complex, final active pharmaceutical ingredients.
• Agrochemical Development: Employed in the research and synthesis of novel pesticides, herbicides, and plant growth regulators.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and contract research organizations (CROs/CMOs).

Basic Information

Product Name	tert-Butyl 4-(4-Amino-3-Methylphenyl)piperazine-1-carboxylate
CAS No.	301672-89-9
Molecular Formula	C16H25N3O2
Molecular Weight	291.39 g/mol
Synonyms	1-Boc-4-(4-Amino-3-methylphenyl)piperazine; tert-Butyl 4-(4-amino-3-methylphenyl)-1-piperazinecarboxylate; 4-(4-Amino-3-methylphenyl)-N-Boc-piperazine; 1-(tert-Butoxycarbonyl)-4-(4-amino-3-methylphenyl)piperazine; 301672-89-9; BOC-4-(4-Amino-3-methylphenyl)piperazine; 4-(4-Amino-3-methylphenyl)piperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(4-Amino-3-Methylphenyl)piperazine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC, Area %)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.