Description

1-Boc-4-(1-Hydroxy-2-Nitroethyl)Piperidine is a high-purity, advanced pharmaceutical intermediate characterized by its unique piperidine scaffold functionalized with both nitro and hydroxyl-protected groups. This compound matters as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), enabling the development of novel therapeutic agents. It is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries for applications in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, particularly those targeting neurological and cardiovascular disorders.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new pharmacologically active molecules.
• Process Chemistry Development: Serves as a standard or starting material for scaling up and optimizing synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Protecting Group Chemistry: The tert-butoxycarbonyl (Boc) group allows for selective protection of amines during complex multi-functional molecule synthesis.
• Nitrogen Heterocycle Library Synthesis: A valuable scaffold for creating diverse compound libraries for high-throughput screening in drug discovery.
• Fine Chemical Synthesis: Employed in the custom synthesis of specialty chemicals and complex organic molecules for various industrial research applications.

Basic Information

Product Name	1-Boc-4-(1-Hydroxy-2-Nitroethyl)Piperidine
CAS No.	301221-56-7
Molecular Formula	C12H22N2O5
Molecular Weight	274.32 g/mol
Synonyms	1-(1,1-Dimethylethyl) 4-(1-Hydroxy-2-Nitroethyl)-1-Piperidinecarboxylate; tert-Butyl 4-(1-Hydroxy-2-Nitroethyl)Piperidine-1-Carboxylate; 4-(1-Hydroxy-2-Nitroethyl)Piperidine-1-Carboxylic Acid tert-Butyl Ester; 1-Boc-4-(1-Hydroxy-2-Nitroethyl)Piperidine; N-Boc-4-(1-Hydroxy-2-Nitroethyl)Piperidine; Piperidine, 4-(1-hydroxy-2-nitroethyl)-, 1-(1,1-dimethylethyl) ester; 1-Boc-4-(2-Nitro-1-hydroxyethyl)piperidine
EINECS	Contact for details

Quality Control

Our 1-Boc-4-(1-Hydroxy-2-Nitroethyl)Piperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the highest standards of purity and consistency required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.