Description

Poly(Ethylene Glycol) Bis(Carboxymethyl) Ether is a versatile, bifunctional polyether derivative featuring terminal carboxylic acid groups. This structure is critical for its role as a hydrophilic spacer and crosslinking agent in advanced material synthesis. It is essential for researchers and manufacturers in the pharmaceutical, biomedical, and specialty polymer industries who require precise functionalization and controlled conjugation. The compound's water solubility and reactive end groups make it a valuable intermediate for creating tailored macromolecules.

Application

• Bioconjugation and Drug Delivery: Serves as a hydrophilic linker for attaching drugs, peptides, or targeting ligands to carriers like proteins, antibodies, or nanoparticles, enhancing solubility and circulation time.
• Hydrogel Formation: Acts as a crosslinker or prepolymer for creating biocompatible hydrogels used in tissue engineering scaffolds, wound dressings, and controlled-release matrices.
• Surface Modification: Used to functionalize material surfaces (e.g., gold, silica, polymers) with carboxyl groups for subsequent biomolecule immobilization, improving biocompatibility.
• Polymer Chemistry Intermediate: A key building block for synthesizing functionalized block copolymers, dendrimers, and star-shaped polymers with tailored properties.
• Chromatography Media: Can be immobilized onto solid supports to create stationary phases for hydrophilic interaction liquid chromatography (HILIC) or affinity chromatography.
• Chelating Agent Synthesis: Used as a precursor for synthesizing polycarboxylate chelators for metal ion binding in analytical or industrial processes.

Basic Information

Product Name	Poly(Ethylene Glycol) Bis(Carboxymethyl) Ether
CAS No.	39927-08-7
Molecular Formula	C2n+4H4n+6On+5 (n = number of ethylene oxide units)
Molecular Weight	Variable (dependent on PEG chain length)
Synonyms	α,ω-Bis(carboxymethoxy)poly(oxy-1,2-ethanediyl); PEG dicarboxymethyl ether; Poly(oxy-1,2-ethanediyl), α,ω-bis(carboxymethoxy)-; Carboxymethyl-PEG-carboxymethyl; Dicarboxylated PEG; HOOC-PEG-COOH; Polyethylene glycol dicarboxylic acid; Poly(ethylene glycol) di(carboxymethyl) ether
EINECS	Contact for details

Quality Control

Our Poly(Ethylene Glycol) Bis(Carboxymethyl) Ether is produced under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure consistency in functionality, purity, and molecular weight distribution. Certificates of Analysis (COA) detailing key parameters such as acid value, degree of substitution, and purity are available upon request. We support compliance with relevant cGMP and ISO 9001 standards for research and industrial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). To prevent degradation and clumping, keep the container tightly sealed in a dry environment and allow it to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Assay (Acid Value)	Contact for details
Average Molecular Weight (GPC)	Specified grade (e.g., 600, 1000, 2000 Da)
Water Content (KF)	< 1.0%
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.