Description

16β-Acetoxy-14,15β-Epoxy-3β,10-Dihydroxy-19-Nor-5β-Bufa-20,22-Dienolide is a high-purity, structurally complex bufadienolide derivative with significant biological activity. This compound serves as a critical advanced pharmaceutical intermediate for research and development in novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on cardiovascular and oncology drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel cardiac glycoside analogs and other bioactive steroidal compounds.
• Biochemical Research: Used as a reference standard or probe in studies investigating Na+/K+-ATPase inhibition and related cellular signaling pathways.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to develop new drug candidates with optimized potency and selectivity.
• Preclinical Development: Employed in the production of compounds for pharmacological evaluation and toxicology studies.

Basic Information

Product Name	16β-Acetoxy-14,15β-Epoxy-3β,10-Dihydroxy-19-Nor-5β-Bufa-20,22-Dienolide
CAS No.	39844-97-8
Molecular Formula	C₂₆H₃₄O₈
Molecular Weight	474.55 g/mol
Synonyms	19-Nor-5β-bufa-20,22-dienolide, 3β,10-dihydroxy-14,15β-epoxy-16β-acetoxy-; 16β-Acetoxy-3β,10,14,15β-tetrahydroxy-19-nor-5β-bufa-20,22-dienolide 14,15β-oxide; 3β,10-Dihydroxy-14,15β-epoxy-16β-acetoxy-19-nor-5β-bufa-20,22-dienolide; Acetylhellebrigenin 3-acetate derivative; Bufadienolide acetate epoxy derivative; 14,15β-Epoxy-16β-acetoxy-3β,10-dihydroxy-19-nor-5β-bufa-20,22-dienolide
EINECS	Contact for details

Quality Control

Our 16β-Acetoxy-14,15β-Epoxy-3β,10-Dihydroxy-19-Nor-5β-Bufa-20,22-Dienolide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research applications. All batches are characterized by advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.