Description

α-Hydroxy-ω-Carboxy Poly(Ethylene Glycol) (PEG-Mw 10,000 Dalton) is a high-purity, heterobifunctional polyethylene glycol derivative featuring a hydroxyl group at one terminus and a carboxylic acid group at the other. This unique bifunctionality is critical for creating custom linkers in bioconjugation, enabling the precise attachment of therapeutic molecules, peptides, or imaging agents. It is an essential building block for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require reliable, well-characterized PEGylation reagents for drug delivery systems, hydrogels, and surface modification.

Application

• Bioconjugation & Drug Delivery: Serves as a versatile linker for PEGylating peptides, proteins, and small molecule drugs to enhance solubility, prolong circulation half-life, and reduce immunogenicity.
• Hydrogel Synthesis: Used as a cross-linking agent or prepolymer for creating biocompatible hydrogels for tissue engineering scaffolds and controlled release matrices.
• Surface Functionalization: Employed to modify nanoparticles, quantum dots, or medical device surfaces with a reactive carboxylic acid group for subsequent covalent immobilization of biomolecules.
• Diagnostic Reagents: Facilitates the development of diagnostic assays by conjugating antibodies or enzymes with labels or solid supports.
• Polymer Chemistry: Acts as a macroinitiator or monomer in ring-opening polymerization and step-growth polymerization to synthesize block or graft copolymers.
• Chemical Biology Probes: Utilized in the synthesis of activity-based probes and affinity tags for proteomics and bioimaging studies.

Basic Information

Product Name	α-Hydroxy-ω-Carboxy Poly(Ethylene Glycol) (PEG-Mw 10,000 Dalton)
CAS No.	39828-93-8
Molecular Formula	HO(CH₂CH₂O)ₙCH₂COOH (n ~ 227)
Molecular Weight	~10,000 Dalton (g/mol)
Synonyms	HO-PEG-COOH; α-Hydroxy-ω-carboxy PEG; Carboxy-PEG-OH; Poly(ethylene glycol) mono(carboxymethyl) ether; mPEG-COOH; PEG-carboxylic acid; Polyoxyethylene mono(carboxymethyl) ether; 8-Aza-2,4,6,10-tetraoxa-9-oxo-1-undecanoic acid, 11-hydroxy-3,6,9-trioxaundecyl-
EINECS	Contact for details

Quality Control

Our α-Hydroxy-ω-Carboxy PEG 10,000 is manufactured under strict quality management systems. Each batch is characterized to ensure critical parameters such as molecular weight distribution (PDI), degree of functionalization, and purity meet stringent specifications. Certificates of Analysis (COA) providing detailed results from HPLC, NMR, and titration analyses are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain optimal reactivity and prevent hydrolysis of the terminal acid group.

Specification

Item	Specification
Appearance	White to off-white waxy solid or powder
Identification (IR)	Complies
Molecular Weight (Mn)	9,500 - 10,500 Da
Polydispersity Index (PDI)	≤ 1.05
Assay (Functional Group)	≥ 95% (by end-group titration)
Water Content (KF)	≤ 1.0 %
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.