Description

trans-3,4-Dihydroxypiperidine is a versatile chiral piperidine derivative, serving as a crucial building block in advanced organic synthesis. Its value lies in its dual hydroxyl functionality and rigid stereochemistry, enabling precise molecular construction for high-value applications. This compound is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers developing active pharmaceutical ingredients (APIs), chiral catalysts, and complex natural product analogs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of potent drug candidates, particularly in neurological and metabolic disorder research.
• Asymmetric Catalyst Ligand: Used to construct sophisticated ligand systems for metal-catalyzed asymmetric reactions, enhancing enantioselectivity.
• Natural Product Synthesis: Serves as a core scaffold in the total synthesis of complex alkaloids and other bioactive natural products.
• Agrochemical Research: Employed in developing novel, stereochemically-defined active ingredients for crop protection.
• Chemical Biology Probe Development: Utilized to create molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Material Science: Acts as a monomer or cross-linker precursor for specialty polymers with tailored properties.

Basic Information

Product Name	trans-3,4-Dihydroxypiperidine
CAS No.	39640-71-6
Molecular Formula	C5H11NO2
Molecular Weight	117.15 g/mol
Synonyms	trans-3,4-Dihydroxypiperidine; (3R,4R)-3,4-Dihydroxypiperidine; (3S,4S)-3,4-Dihydroxypiperidine; 3,4-Piperidinediol, (3R,4R)-rel-; 3,4-Dihydroxy-piperidine; Piperidine-3,4-diol; 39640-71-6; (rac)-(3R,4R)-3,4-Dihydroxypiperidine
EINECS	Contact for details

Quality Control

Our trans-3,4-Dihydroxypiperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical and advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.