Description

2-Amino-5-(4-Methylpiperazinyl)Benzenecarbonitrile is a high-value pharmaceutical intermediate featuring a unique benzonitrile core substituted with amino and methylpiperazinyl groups. This compound matters for its critical role as a versatile building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. Pharmaceutical R&D and fine chemical manufacturers need this intermediate for developing new drug candidates, leveraging its structural motifs to impart specific biological activity and pharmacokinetic properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in multi-step synthetic routes to construct complex molecules for clinical development.
• Chemical Biology & Medicinal Chemistry: Serves as a scaffold for creating compound libraries to explore structure-activity relationships (SAR).
• Research & Development (R&D): Employed in academic and industrial laboratories for the discovery of new therapeutic agents.
• Fine Chemical Manufacturing: Integrated into custom synthesis and contract manufacturing projects for specialized chemical production.

Basic Information

Product Name	2-Amino-5-(4-Methylpiperazinyl)Benzenecarbonitrile
CAS No.	38943-98-5
Molecular Formula	C12H16N4
Molecular Weight	216.29 g/mol
Synonyms	2-Amino-5-(4-methyl-1-piperazinyl)benzonitrile; 5-(4-Methylpiperazin-1-yl)-2-aminobenzonitrile; 2-Amino-5-(N-methylpiperazino)benzonitrile; Benzonitrile, 2-amino-5-(4-methyl-1-piperazinyl)-; 38943-98-5; 2-Amino-5-(4-methylpiperazin-1-yl)benzonitrile
EINECS	Contact for details

Quality Control

Our 2-Amino-5-(4-Methylpiperazinyl)Benzenecarbonitrile is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. We adhere to ICH Q7 guidelines and relevant good manufacturing practices. Comprehensive analytical testing is performed, and a Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, consider keeping under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.