Description

Taurohyodeoxycholic Acid Sodium Salt Hydrate is a high-purity conjugated bile acid derivative, specifically the taurine conjugate of hyodeoxycholic acid. This compound is of significant value in biochemical and pharmaceutical research due to its role as a reference standard and a key intermediate in the study of bile acid metabolism and signaling pathways. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic manufacturers focused on hepatology, gastroenterology, and metabolic disorders.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of bile acids in drug development and quality control processes.
• Biochemical Research: Serves as a critical reagent and substrate in studies investigating bile acid transporters, receptors (e.g., FXR, TGR5), and metabolic enzymes.
• Cell Culture & In Vitro Studies: Employed in hepatocyte and intestinal cell culture models to study cholestasis, cytotoxicity, and cytoprotective effects.
• Diagnostic Kit Manufacturing: Acts as a calibrator or component in enzymatic and chromatographic assay kits for clinical bile acid profiling.
• Metabolite Synthesis: Used as a starting material or intermediate for the synthesis of more complex bile acid analogs and labeled compounds for tracer studies.

Basic Information

Product Name	Taurohyodeoxycholic Acid Sodium Salt Hydrate
CAS No.	38411-85-7
Molecular Formula	C26H44NNaO7S · xH2O
Molecular Weight	Anhydrous: 537.68 g/mol
Synonyms	Sodium Taurohyodeoxycholate Hydrate; THDCA Sodium Salt; 3α,6α-Dihydroxy-5β-cholan-24-oyltaurine Sodium Salt; N-[(3α,6α-Dihydroxy-5β-cholan-24-oyl)]-2-aminoethanesulfonate Sodium Salt; Hyodeoxycholyltaurine Sodium Salt; Tauro-α,β-hyodeoxycholic Acid Sodium Salt; Sodium Tauro-α-hyodeoxycholate
EINECS	Contact for details

Quality Control

Our Taurohyodeoxycholic Acid Sodium Salt Hydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specific results for that lot.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Related Substances (HPLC)	Total impurities ≤5.0%
Solubility	Soluble in water and methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.