Description

3-cis-Hydroxyglipizide is a key chemical intermediate and reference standard with significant importance in pharmaceutical research and development. This compound is primarily valued for its role in the synthesis and analytical characterization of active pharmaceutical ingredients (APIs) within the sulfonylurea class. It is essential for researchers and manufacturers in the pharmaceutical industry, particularly those focused on metabolic disorders, who require high-purity building blocks for drug development and quality control processes.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced sulfonylurea-based active pharmaceutical ingredients (APIs).
• Analytical Reference Standard: Used for method development, validation, and quality control (QC) testing in pharmaceutical laboratories to ensure product purity and consistency.
• Metabolic Disorder Research: Serves as a key compound in preclinical and clinical research targeting diabetes and related metabolic conditions.
• Process Chemistry: Employed in route scouting and optimization for the scalable manufacturing of related therapeutic compounds.
• Impurity Profiling: Utilized as a certified reference material to identify and quantify related substances and degradation products in final drug formulations.

Basic Information

Product Name	3-cis-Hydroxyglipizide
CAS No.	38207-37-3
Molecular Formula	C21H27N5O4S
Molecular Weight	445.54 g/mol
Synonyms	3-cis-Hydroxy Glipizide; 5-Methyl-N-[2-[4-[[[(cis-3-hydroxycyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-pyrazinecarboxamide; Glipizide Impurity F (cis); 3-Hydroxyglipizide (cis-isomer); Cyclohexanol, 3-amino-, cis-, compd. with 1-cyclohexyl-3-[[p-[2-(5-methylpyrazine-2-carboxamido)ethyl]phenyl]sulfonyl]urea; cis-3-Hydroxyglipizide
EINECS	Contact for details

Quality Control

Our 3-cis-Hydroxyglipizide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.