Description

1-((1-(2-Methoxyphenyl)-5-Oxo-3-Pyrrolidinyl)Carbonyl)Piperazine Monohydrochloride is a high-purity, non-racemic pharmaceutical intermediate with a complex heterocyclic structure. This compound matters for its critical role as a key building block in the synthesis of advanced active pharmaceutical ingredients (APIs), where precise stereochemistry and purity are paramount. It is primarily needed by R&D chemists and process development teams in the pharmaceutical and biotechnology industries for the production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral precursor in the multi-step synthesis of complex drug molecules, particularly in central nervous system (CNS) and cardiovascular research.
• API Synthesis: Used in the development and scale-up manufacturing of Active Pharmaceutical Ingredients (APIs) requiring a specific pyrrolidinyl-piperazine scaffold.
• Process Chemistry & Optimization: Employed in route scouting and process refinement to improve yield, purity, and cost-efficiency of final drug substances.
• Chemical Reference Standard: Acts as a high-purity standard for analytical method development, validation, and quality control in regulatory submissions.
• Medicinal Chemistry Research: Provides a versatile template for structure-activity relationship (SAR) studies and the creation of novel chemical libraries for biological screening.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for cGMP production of clinical trial materials and commercial APIs.

Basic Information

Product Name	1-((1-(2-Methoxyphenyl)-5-Oxo-3-Pyrrolidinyl)Carbonyl)Piperazine Monohydrochloride
CAS No.	38160-10-0
Molecular Formula	C17H22ClN3O3
Molecular Weight	351.83 g/mol
Synonyms	1-[(1-(2-Methoxyphenyl)-5-oxo-3-pyrrolidinyl)carbonyl]piperazine hydrochloride; 1-((1-(2-Methoxyphenyl)-5-oxo-3-pyrrolidinyl)carbonyl)piperazine HCl; Piperazine, 1-[(1-(2-methoxyphenyl)-5-oxo-3-pyrrolidinyl)carbonyl]-, monohydrochloride; (S)-1-((1-(2-Methoxyphenyl)-5-oxo-3-pyrrolidinyl)carbonyl)piperazine hydrochloride (common for single enantiomer); UNII-8V6T7Q8KQN; 38160-10-0; 1-Piperazinecarboxylic acid, 4-[1-(2-methoxyphenyl)-5-oxo-3-pyrrolidinyl]-, monohydrochloride
EINECS	Contact for details

Quality Control

Our 1-((1-(2-Methoxyphenyl)-5-Oxo-3-Pyrrolidinyl)Carbonyl)Piperazine Monohydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets exacting standards for pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, residual solvents, and related substances is provided with every shipment to support your regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.