Description

4-(3-Trifluoromethyl-Benzyl)-Piperidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine core and trifluoromethyl-benzyl substituent. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting the central nervous system. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its piperidine scaffold and fluorine chemistry.
• Ligand Synthesis: Serves as a precursor for the development of receptor ligands and enzyme inhibitors in biochemical assays.
• Fine Chemical Production: Employed in multi-step organic synthesis for creating complex, high-value specialty chemicals.
• Academic & Industrial R&D: A valuable reagent for exploratory research in organic synthesis and new chemical entity development.

Basic Information

Product Name	4-(3-Trifluoromethyl-Benzyl)-Piperidine Hydrochloride
CAS No.	37581-29-6
Molecular Formula	C13H16ClF3N
Molecular Weight	278.72 g/mol
Synonyms	4-[(3-Trifluoromethyl)benzyl]piperidine hydrochloride; 1-[(3-Trifluoromethyl)phenyl]methyl-4-piperidinyl hydrochloride; 4-(3-(Trifluoromethyl)benzyl)piperidine HCl; Piperidine, 4-[(3-(trifluoromethyl)phenyl)methyl]-, hydrochloride (1:1); 37581-29-6; 4-(alpha,alpha,α-Trifluoro-m-tolyl)piperidine hydrochloride
EINECS	Contact for details

Quality Control

Our 4-(3-Trifluoromethyl-Benzyl)-Piperidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and relevant industry standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.