Description

Phorbol-12,13-Dihexanoate is a synthetic, cell-permeable ester derivative of the natural phorbol diterpene. This compound is a potent and specific activator of protein kinase C (PKC) isoforms, making it a critical research tool in cell signaling and pharmacological studies. It is primarily utilized by researchers and scientists in the fields of biochemistry, oncology, and molecular biology for investigating PKC-mediated pathways, tumor promotion, and cellular differentiation mechanisms.

Application

• Biochemical Research: A standard tool for activating Protein Kinase C (PKC) in cell-based assays and signal transduction studies.
• Oncology Research: Used to study PKC's role in tumor promotion, cell proliferation, and apoptosis.
• Pharmacology: Employed as a reference agonist in high-throughput screening for PKC inhibitor drug discovery.
• Neuroscience: Applied in research on PKC's function in neurotransmitter release, synaptic plasticity, and neuronal differentiation.
• Immunology: Utilized to investigate PKC signaling in immune cell activation, cytokine production, and inflammatory responses.
• Cell Biology: A key reagent for studying the effects of PKC activation on cellular processes like secretion, membrane trafficking, and cytoskeletal reorganization.

Basic Information

Product Name	Phorbol-12,13-Dihexanoate
CAS No.	37558-17-1
Molecular Formula	C34H52O8
Molecular Weight	588.78 g/mol
Synonyms	PDBu; Phorbol 12,13-Dibutyrate (common analog name); 12,13-Dihexanoylphorbol; 4,9,12-beta,13-alpha,20-Pentahydroxytiglia-1,6-dien-3-one 12,13-dihexanoate; NSC 11905; Phorbol-12,13-dihexanoic acid ester; 1,1a,1b,4,4a,7a,7b,8,9,9a-Decahydro-4a,7b,9,9a-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one 12,13-dihexanoate
EINECS	Contact for details

Quality Control

Our Phorbol-12,13-Dihexanoate is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, ensuring reliable performance in your experimental systems.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, ethanol, acetone

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.