Description

(S)-2-Hydroxy-2-Methylbutyric Acid CAS NO 37505-07-0 is a high-purity chiral building block essential for the synthesis of advanced pharmaceutical intermediates and fine chemicals. Its defined stereochemistry provides a critical advantage in creating enantiomerically pure compounds with targeted biological activity. This product is primarily required by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and high-value chiral molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the production of active pharmaceutical ingredients (APIs), particularly in cardiovascular and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the manufacture of enantiomerically pure herbicides and pesticides, where specific stereochemistry enhances efficacy and reduces environmental impact.
• Fine Chemical Production: Serves as a versatile building block for synthesizing complex molecules in flavors, fragrances, and advanced materials.
• Biochemical Research: Employed as a standard or reagent in enzymatic studies and metabolic pathway research due to its specific (S)-configuration.
• Catalyst and Ligand Development: Utilized in the preparation of chiral catalysts and ligands for asymmetric synthesis.
• Polymer Modification: Acts as a monomer or modifying agent for creating polymers with specific chiral centers or functional groups.

Basic Information

Product Name	(S)-2-Hydroxy-2-Methylbutyric Acid
CAS No.	37505-07-0
Molecular Formula	C5H10O3
Molecular Weight	118.13 g/mol
Synonyms	(S)-2-Hydroxy-2-methylbutanoic acid; (S)-2-Methyl-2-hydroxybutyric acid; L-2-Hydroxy-2-methylbutyric acid; (2S)-2-Hydroxy-2-methylbutanoic acid; (S)-α-Hydroxy-α-methylbutyric acid; 2-Hydroxy-2-methylbutyric acid, (S)-; Butanoic acid, 2-hydroxy-2-methyl-, (2S)-
EINECS	Contact for details

Quality Control

Our (S)-2-Hydroxy-2-Methylbutyric Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets stringent specifications for pharmaceutical and fine chemical applications. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent absorption of atmospheric moisture, which can affect product quality and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	85 - 90 °C
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.