Description

1-(8-Chloro-2,3,4,5-tetrahydro-1-benzoxepin-5-yl)-4-phenylpiperazine maleate hydrate is a high-purity, non-racemic pharmaceutical intermediate and research chemical. This compound is valued for its role as a key chiral building block in the synthesis of complex active pharmaceutical ingredients (APIs) and for pharmacological research applications. It is primarily sought by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the multi-step synthesis of advanced therapeutic compounds.
• Medicinal Chemistry Research: Used as a standard or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Serves as a key material for developing and scaling up robust, cost-effective synthetic routes for target molecules.
• Reference Standard: Employed as an analytical standard for quality control, method development, and regulatory submissions.
• Biochemical Research: Utilized in vitro studies to investigate specific biological pathways and receptor interactions.

Basic Information

Product Name	1-(8-Chloro-2,3,4,5-tetrahydro-1-benzoxepin-5-yl)-4-phenylpiperazine maleate hydrate
CAS No.	37483-86-6
Molecular Formula	C23H27ClN2O5
Molecular Weight	446.92 g/mol
Synonyms	1-(8-Chloro-2,3,4,5-tetrahydro-1-benzoxepin-5-yl)-4-phenylpiperazine (Z)-butenedioate hydrate; 1-(8-Chloro-2,3,4,5-tetrahydro-1-benzoxepin-5-yl)-4-phenylpiperazine maleic acid salt hydrate; 5-[(4-Phenyl-1-piperazinyl)methyl]-8-chloro-2,3,4,5-tetrahydro-1-benzoxepin maleate hydrate; (5S)-1-(8-Chloro-2,3,4,5-tetrahydro-1-benzoxepin-5-yl)-4-phenylpiperazine maleate hydrate; (S)-1-(8-Chloro-2,3,4,5-tetrahydro-1-benzoxepin-5-yl)-4-phenylpiperazine maleate hydrate; Benzoxepin derivative maleate salt.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to ensure identity, purity, and enantiomeric excess meet rigorous specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.