Description

Phosphorothioic Acid S-[2-[(6-Aminohexyl)Amino]Ethyl] Ester is a specialized bifunctional organophosphorus compound featuring both a reactive phosphorothioate group and a primary amine-terminated alkyl chain. This unique structure makes it a valuable intermediate for creating covalent linkages in advanced material science and bioconjugation applications. It is particularly essential for researchers and manufacturers in the pharmaceutical, diagnostics, and polymer industries who require precise molecular coupling agents.

Application

• Bioconjugation Reagent: Used for coupling biomolecules (e.g., proteins, antibodies, oligonucleotides) to surfaces, nanoparticles, or other polymers via its amine-reactive phosphorothioate group.
• Polymer Modification & Cross-linking Agent: Serves as a functional monomer or cross-linker to introduce amine or phosphorothioate functionalities into polymer backbones, enhancing properties like adhesion or bioactivity.
• Surface Functionalization: Applied to modify the surface of materials (glass, metals, plastics) to create amine-reactive platforms for subsequent immobilization chemistry.
• Pharmaceutical Intermediate: Acts as a key building block in the synthesis of prodrugs or targeted therapeutic agents that utilize phosphate/thiophosphate metabolization pathways.
• Diagnostic Assay Development: Employed in the fabrication of biosensors and diagnostic kits where stable, covalent attachment of capture molecules is critical.
• Material Science Research: Utilized in R&D for developing novel functional materials, hydrogels, and smart coatings with tailored interfacial properties.

Basic Information

Product Name	Phosphorothioic Acid S-[2-[(6-Aminohexyl)Amino]Ethyl] Ester
CAS No.	36416-85-0
Molecular Formula	C8H21N2O2PS
Molecular Weight	240.31 g/mol
Synonyms	S-[2-[(6-Aminohexyl)amino]ethyl] phosphorothioate; 2-[(6-Aminohexyl)amino]ethanethiol O-hydrogen phosphorothioate; Amino-PEG2-C6-Phosphorothioate (common descriptor); Aminoalkyl phosphorothioate ester; N-(6-Aminohexyl)-2-aminoethyl phosphorothioate; Amino-terminated phosphorothioate linker; Phosphorothioate-PEG-amine derivative
EINECS	Contact for details

Quality Control

Our production of Phosphorothioic Acid S-[2-[(6-Aminohexyl)Amino]Ethyl] Ester adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as identity, assay, and impurity profiles. We maintain a quality management system aligned with cGMP principles for pharmaceutical intermediates, and specifications can be tailored to meet specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or viscous oil
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.