Description

3,4-Dimethylbenzylmagnesium Chloride is a versatile organometallic reagent, specifically a Grignard reagent, widely used in organic synthesis for the formation of carbon-carbon bonds. Its value lies in its ability to act as a nucleophilic benzylating agent, introducing the 3,4-dimethylbenzyl moiety into a wide range of electrophiles to construct complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require high-purity intermediates for the development of active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for introducing the 3,4-dimethylbenzyl group into target molecules during the research and development of new drug candidates.
• Agrochemical Active Ingredient Production: Used in the synthesis of herbicides, fungicides, and insecticides that incorporate substituted benzyl structures.
• Fine Chemical and Specialty Material Manufacturing: Employed in the creation of liquid crystals, organic semiconductors, and performance polymers requiring specific aromatic substitutions.
• Academic and R&D Laboratories: A fundamental reagent for methodological development in organic chemistry and catalysis studies.
• Cross-Coupling Reactions: Serves as a coupling partner in transition-metal catalyzed reactions, such as Kumada couplings, to form biaryl structures.
• Nucleophilic Addition to Carbonyls: Reacts with aldehydes, ketones, esters, and carbon dioxide to yield secondary/tertiary alcohols and carboxylic acids.

Basic Information

Product Name	3,4-Dimethylbenzylmagnesium Chloride
CAS No.	36229-43-3
Molecular Formula	C9H11ClMg
Molecular Weight	178.94 g/mol
Synonyms	3,4-Dimethylbenzylmagnesium Chloride; (3,4-Dimethylphenyl)methylmagnesium Chloride; 3,4-Dimethylbenzyl Grignard Reagent; Magnesium, chloromethylbis(3,4-dimethylphenyl)-; 3,4-Xylylmagnesium Chloride; 3,4-Dimethylbenzyl Magnesium Chloride Solution; Grignard Reagent, 3,4-Dimethylbenzylmagnesium Chloride
EINECS	Contact for details

Quality Control

Every batch of 3,4-Dimethylbenzylmagnesium Chloride is produced and tested under stringent quality management protocols to ensure consistency and reliability for critical synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as concentration, active Grignard content, and impurity profile. Our quality systems are designed to meet the exacting standards required for cGMP intermediate manufacturing and high-purity research applications.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive) and highly volatile. It must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated area. Recommended storage temperature is 2-8°C. Keep away from heat, sparks, open flames, and strong oxidizers.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Concentration (in THF or Ether)	0.5 M - 2.0 M (Custom)
Assay (Titration)	≥ 95% (as Grignard Reagent)
Identification (IR/NMR)	Conforms to structure
Water Content (Karl Fischer)	< 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.