Description

2,5-Difluorobenzoyl Chloride is a high-purity, reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms on the benzene ring, which significantly influences the electronic properties and metabolic stability of final target molecules. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it is used to introduce the 2,5-difluorobenzoyl moiety into complex structures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the difluoro substitution pattern enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing aromatic cores in electronic materials, improving thermal stability and optical properties.
• Polymer Modification: Employed to introduce fluorinated benzoyl groups into polymer chains, altering surface properties, chemical resistance, and durability.
• Peptide & Protein Research: Useful as an acylating agent for modifying amino acids or protecting groups in peptide synthesis.
• Dye & Pigment Manufacturing: Intermediate in the production of specialized fluorinated dyes and pigments with unique color fastness and spectral characteristics.

Basic Information

Product Name	2,5-Difluorobenzoyl Chloride
CAS No.	35730-09-7
Molecular Formula	C7H3ClF2O
Molecular Weight	176.55 g/mol
Synonyms	2,5-Difluorobenzoic acid chloride; 2,5-Difluorobenzoyl chloride; Benzoic acid, 2,5-difluoro-, chloride; 2,5-Difluorobenzoic acid chloride; 2,5-Difluorobenzoylchloride; 2,5-Difluorobenzoyl Chloride (2,5-DFBC); 35730-09-7; 2,5-Difluorobenzoylchlorid (German)
EINECS	Contact for details

Quality Control

Our 2,5-Difluorobenzoyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 15-25°C. Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.