Description

3-Hydroxy-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a versatile and high-purity piperidine derivative, serving as a critical protected intermediate in advanced organic synthesis. Its value lies in the tert-butyloxycarbonyl (Boc) protecting group, which provides excellent stability under a wide range of reaction conditions while allowing for selective deprotection. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, where it is used to construct complex molecular scaffolds for active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of piperidine-based drug candidates, including potential central nervous system (CNS) agents and enzyme inhibitors.
• Peptide Mimetics & PROTACs: Used in the construction of peptidomimetics and Proteolysis Targeting Chimeras (PROTACs) due to its chiral hydroxyl functionality and protected amine.
• Agrochemical Synthesis: Intermediate in the development of novel herbicides, fungicides, and insecticides that incorporate the piperidine moiety.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Custom Synthesis & R&D: A valuable starting material for contract research organizations (CROs) and academic laboratories exploring new chemical entities.
• Scale-up for API Production: Suitable for process development and cGMP manufacturing of active pharmaceutical ingredients (APIs) requiring this specific protected intermediate.

Basic Information

Product Name	3-Hydroxy-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	35133-42-7
Molecular Formula	C10H19NO3
Molecular Weight	201.26 g/mol
Synonyms	1-Boc-3-hydroxypiperidine; tert-Butyl 3-hydroxypiperidine-1-carboxylate; 3-Hydroxy-1-(tert-butoxycarbonyl)piperidine; 1-N-Boc-3-piperidinol; 3-Hydroxy-N-Boc-piperidine; 3-Piperidinol, 1-[(1,1-dimethylethoxy)carbonyl]-; Piperidine-1-carboxylic acid, 3-hydroxy-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay and impurity profiles. Our quality commitment supports applications requiring high standards, including cGMP and ISO-guided processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.